CMR substances: New Regulation for Cosmetic Products What are CMR substances in cosmetics? CMR substances are carcinogenic, mutagenic or toxic to reproduction. In the EU they are classified under the CLP Regulation (EC) No 1272/2008 into: Category 1A (known human evidence), 1B (presumed from animal data) and 2 (suspected). These classifications are used across chemical legislation and are the basis for cosmetic...